VACUOLIN-1 ENHANCES RA-INDUCED DIFFERENTIATION OF HUMAN MYELOBLASTIC LEUKEMIA CELLS: EVIDENCE FOR INVOLVEMENT OF A CD11B/FAK/LYN/SLP-76 AXIS SUBJECT TO ENDOSOMAL REGULATION THAT DRIVES LATE DIFFERENTIATION STEPS

Abstract Background Retinoic acid(RA), an embryonic morphogen, regulates cell differentiation.Endocytosis regulates receptor signaling that governs such RA-directed cellular processes.Vacuolin-1 is a small molecule that disrupts endocytosis, motivating interest in its effect on RA-induced differentiation/arrest.In Outer Door Moulding HL-60 myelobla

Background: False-positive blood cultures compromise care; extended stays, Clostridioides difficile risk increases and renal woes tagged to antibiotic alms contribute to the doubling of patient in-hospital mortality that is observed relative to true negative diagnostic results.False-positive affiliated central line-associated bloodstream infection

Mirror Therapy is a form of upper limb therapy in stroke, which consists on showing the mirrored symmetric movement of the unimpaired side using a mirror placed in the medial sagittal plane.The illusion of movement corresponding to the impaired extremity could facilitate neuroplasticity, and assists patients in regaining certain lost motor function